Hello Tom. That's a great question. I'm not sure if you are familiar with leaky gut - but it's a by product of food fermenting in your gut. As discusting as it sounds, it's happening all the time. If you always have an influx of good bacteria - you are in luck. Unfortunately it's not something we all experience. If you would like to read more about it, check out this research. https://pubmed.ncbi.nlm.nih.gov/31717475/